In vivo, 167 improved motor features in MPTP-induced Parkinson’s mice, restored dopamine concentrations in the striatum, and decreased oxidative stress and neuroinflammation by reducing the activation of microglia and astrocytes. The neuroprotective effects were accomplished by upregulating antioxidative enzymes including SOD2, NRF2, and NQO1, highlighting the potential of 167 as a therapeutic agent for Parkinson’s condition.
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This overview aims to summarize the new innovations in a variety of procedures for that synthesis of indazole derivatives. The present developments inside the biological actions of indazole-based compounds can also be introduced.
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